The COVID-19 pandemic, like many crises before it, has disproportionally affected Black and LatinX communities, once again exposing the ingrained racism limiting people’s access to healthcare, employment, education, and stable housing. Achieving deeper racial equity in communities across the country requires taking on existing power structures and working to change the systems that sustain racism. A new set of place-based initiatives is working to change these systems through three avenues: structural changes in policies, practices, and resource flows; relational changes in networks and power; and transforming attitudes.